• Inflamatory bowel disease and other inmune system associated-diseases

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• Segmental Regulation of Intestinal Motility by Colitis and the Adaptive Immune System in the Mouse Ileum and Colon. Gomez-Bris R, Rodríguez-Rodríguez P, Ortega-Zapero M, Ruvira S, Castillo-González R, Fernández-Aceñero MJ, Cruz-Adalia A, Saez A, Arribas SM, Gonzalez-Granado JM. Am J Pathol. 2025 Feb;195(2):204-220. doi: 10.1016/j.ajpath.2024.10.020. PMID: 39561965

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• IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis. Valle-Noguera A, Sancho-Temiño L, Castillo-González R, Villa-Gómez C, Gomez-Sánchez MJ, Ochoa-Ramos A, Yagüe-Fernández P, Soler Palacios B, Zorita V, Raposo-Ponce B, González-Granado JM, Aragonés J, Cruz-Adalia A. Cell Rep. 2023 Dec 26;42(12):113508. doi: 10.1016/j.celrep.2023.113508. PMID: 38019650

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• CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease. Gomez-Bris R, Saez A, Herrero-Fernández B, Rius, C, Sanchez-Martinez H, Gonzalez-Granado JM. Int J Mol Sci. 2023 Jan 31;24(3):2696. doi: 10.3390/ijms24032696. PMID: 36769019

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• Pathophysiology of Inflammatory Bowel Disease: Innate Immune System.  Saez A, Herrero-Fernández B, Gomez-Bris R, Sanchez-Martinez H, Gonzalez-Granado JM. Int J Mol Sci . 2023 Jan 12;24(2):1526. doi: 10.3390/ijms24021526. PMID: 36675038

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• Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease. Saez A, Gomez-Bris R, Herrero-Fernandez B, Mingorance C, Rius C, Gonzalez-Granado JM.Int J Mol Sci . 2021 Jul 16;22(14):7618. doi: 10.3390/ijms22147618.PMID: 34299236

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• Lamin A/C deficiency in CD4+ T-cells enhances regulatory T-cells and prevents inflammatory bowel disease. Toribio-Fernández R, Herrero-Fernandez B, Zorita V, López JA, Vázquez J, Criado G, Pablos JL, Collas P, Sánchez-Madrid F, Andrés V, Gonzalez-Granado JM. J Pathol. 2019 Dec;249(4):509-522. doi: 10.1002/path.5332. PMID: 31372995

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• Immunobiology of Atherosclerosis: A Complex Net of Interactions. Herrero-Fernandez B, Gomez-Bris R, Somovilla-Crespo B, Gonzalez-Granado JM. Int J Mol Sci. 2019 Oct 24;20(21):5293. doi: 10.3390/ijms20215293. PMID: 31653058

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• T-cells, APCs and Lamin A/C:

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• Role of lamin A/C on dendritic cell function in antiviral immunity. Herrero-Fernández B, Ortega-Zapero M, Gómez-Bris R, Sáez A, Iborra S, Zorita V, Quintas A, Vázquez E, Dopazo A, Sánchez-Madrid F, Arribas SM, González-Granado JM. Cell Mol Life Sci. 2024 Sep 12;81(1):400. doi: 10.1007/s00018-024-05423-9

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• Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages. De Silva NS, Siewiera J, Alkhoury C, Nader GPF, Nadalin F, de Azevedo K, Couty M, Izquierdo HM, Bhargava A, Conrad C, Maurin M, Antoniadou K, Fouillade C, Londono-Vallejo A, Behrendt R, Bertotti K, Serdjebi C, Lanthiez F, Gallwitz L, Saftig P, Herrero-Fernández B, Saez A, González-Granado JM, van Niel G, Boissonnas A, Piel M, Manel N. Nat Aging. 2023 Oct;3(10):1251-1268. doi: 10.1038/s43587-023-00488-w. PMID: 37723209

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• Lamin A/C and the Immune System: One Intermediate Filament, Many Faces. Saez A, Herrero-Fernandez B, Gomez-Bris R, Somovilla-Crespo B, Rius C, Gonzalez-Granado JM. Int J Mol Sci 2020 Aug 25;21(17):6109. doi: 10.3390/ijms21176109. PMID: 32854281

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• The nucleus acts as a ruler tailoring cell responses to spatial constraints. Lomakin AJ, Cattin CJ, Cuvelier D, Alraies Z, Molina M, Nader GPF, Srivastava N, Sáez PJ, Garcia-Arcos JM, Zhitnyak IY, Bhargava A, Driscoll MK, Welf ES, Fiolka R, Petrie RJ, De Silva NS, González-Granado JM, Manel N, Lennon-Duménil AM, Müller DJ, Piel M.Science. 2020 Oct 16;370(6514):eaba2894. doi: 10.1126/science.aba2894. PMID: 33060332

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• Proliferation and Th1 Differentiation Induced by Bone Marrow-derived Dendritic Cells. Toribio-Fernandez, R, Zorita, V, Herrero-Fernandez, B, Gonzalez-Granado, JM. An In Vivo Mouse Model to Measure Naïve CD4 T Cell Activation,  J. Vis. Exp. 2018 (138), e58118, doi:10.3791/58118.

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• Lamin A/C augments Th1 differentiation and response against vaccinia virus and Leishmania major. Toribio-Fernández R, Zorita V, Rocha-Perugini V, Iborra S, Martínez Del Hoyo G, Chevre R, Dorado B, Sancho D, Sanchez-Madrid F, Andrés V, Gonzalez-Granado JM. Cell Death Dis. 2018 Jan 8;9(1):9. doi: 10.1038/s41419-017-0007-6. PMID: 29311549.

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• Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation. González-Granado JM, Silvestre-Roig C, Rocha-Perugini V, Trigueros-Motos L, Cibrián D, Morlino G, Blanco-Berrocal M, Osorio FG, Freije JMP, López-Otín C, Sánchez-Madrid F, Andrés V. Sci Signal. 2014 Apr 22;7(322):ra37. doi: 10.1126/scisignal.2004872. PMID: 24757177.

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• Nuclear envelope lamin-A as a coordinator of T cell activation. Rocha-Perugini V, González-Granado JM. Nucleus. 2014 Sep-Oct;5(5):396-401. doi: 10.4161/nucl.36361. PMID: 25482193

• In Vitro Differentiation of Naïve CD4⁺ T Cells: A Tool for Understanding the Development of Atherosclerosis. Iborra S, González-Granado JM. Methods Mol Biol. 2015;1339:177-89. doi: 10.1007/978-1-4939-2929-0_12. PMID: 26445789

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• Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses. Cruz-Adalia A, Ramirez-Santiago G, Osuna-Pérez J, Torres-Torresano M, Zorita V, Martínez-Riaño A, Boccasavia V, Borroto A, Martínez Del Hoyo G, González-Granado JM, Alarcón B, Sánchez-Madrid F, Veiga E. Nat Commun. 2017 Nov 17;8(1):1591. doi: 10.1038/s41467-017-01661-7. PMID: 29147022.

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• Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity. Morlino G, Barreiro O, Baixauli F, Robles-Valero J, González-Granado JM, Villa-Bellosta R, Cuenca J, Sánchez-Sorzano CO, Veiga E, Martín-Cófreces NB, Sánchez-Madrid F. Mol Cell Biol. 2014 Apr;34(8):1412-26. doi: 10.1128/MCB.01177-13. Epub 2014 Feb 3. PMID: 24492963.

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• Tetraspanins 

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• CD9 Regulates Major Histocompatibility Complex Class II Trafficking in Monocyte-Derived Dendritic Cells. Rocha-Perugini V, Martínez Del Hoyo G, González-Granado JM, Ramírez-Huesca M, Zorita V, Rubinstein E, Boucheix C, Sánchez-Madrid F. Mol Cell Biol. 2017 Jul 14;37(15). pii: e00202-17. doi: 10.1128/MCB.00202-17. Print 2017 Aug 1. PMID: 28533221

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• Tetraspanins CD9 and CD151 at the immune synapse support T-cell integrin signaling. Rocha-Perugini V, González-Granado JM, Tejera E, López-Martín S, Yañez-Mó M, Sánchez-Madrid F. Eur J Immunol. 2014 Jul;44(7):1967-75. doi: 10.1002/eji.201344235. Epub 2014 Apr 29. PMID: 24723389 

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• CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses. Rocha-Perugini V, Zamai M, González-Granado JM, Barreiro O, Tejera E, Yañez-Mó M, Caiolfa VR, Sanchez-Madrid F. Mol Cell Biol. 2013 Sep;33(18):3644-58. doi: 10.1128/MCB.00302-13. Epub 2013 Jul 15. PMID: 23858057

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• Cellularity of inflammation:

• Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic Mice. Pan C, Herrero-Fernandez B, et al Circulation. 2023 Feb 28;147(9):774-777

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• High-resolution imaging of intravascular atherogenic inflammation in live mice. Chèvre R, González-Granado JM, Megens RT, Sreeramkumar V, Silvestre-Roig C, Molina-Sánchez P, Weber C, Soehnlein O, Hidalgo A, Andrés V. Circ Res. 2014 Feb 28;114(5):770-9. doi: 10.1161/CIRCRESAHA.114.302590. Epub 2013 Dec 23. PMID: 24366169

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• β2-Adrenoceptor signaling in airway epithelial cells promotes eosinophilic inflammation, mucous metaplasia, and airway contractility. Nguyen LP, Al-Sawalha NA, Parra S, Pokkunuri I, Omoluabi O, Okulate AA, Windham Li E, Hazen M, Gonzalez-Granado JM, Daly CJ, McGrath JC, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9163-E9171. doi: 10.1073/pnas.1710196114. Epub 2017 Oct 9. PMID: 29073113

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• Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. Vila-Caballer M, González-Granado JM, Zorita V, Abu Nabah YN, Silvestre-Roig C, Del Monte-Monge A, Molina-Sánchez P, Ait-Oufella H, Andrés-Manzano MJ, Sanz MJ, Weber C, Kremer L, Gutiérrez J, Mallat Z, Andrés V. J Mol Cell Cardiol. 2019 Jul;132:154-163. doi: 10.1016/j.yjmcc.2019.05.009. PMID: 31121182

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• Immunobiology of Atherosclerosis: A Complex Net of Interactions. Herrero-Fernandez B, Gomez-Bris R, Somovilla-Crespo B Gonzalez-Granado JM Int. J. Mol. Sci. 2019, 20(21), 5293; doi: 10.3390/ijms20215293

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• Lamin A/C and nucleus physiology:

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• Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope. González-Granado JM, Navarro-Puche A, Molina-Sanchez P, Blanco-Berrocal M, Viana R, Font de Mora J, Andrés V. PLoS One. 2014 Dec 23;9(12):e115571. doi: 10.1371/journal.pone.0115571. eCollection 2014. PMID: 25535984

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• Other topics

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• Fetal programming and lactation: modulating gene expression in response to undernutrition during intrauterine life. Monedero Cobeta I, Gomez Bris R, Rodríguez-Rodríguez P, Saez A, Quintana-Villamandos B, González Granado JM, Arribas SM. Pediatr Res. 2024 Jun;95(7):1764-1774. doi: 10.1038/s41390-024-03042-5. Epub 2024 Feb 7. PMID: 38326476

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