• Inflamatory bowel disease and other inmune system associated-diseases

• CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease. Gomez-Bris R, Saez A, Herrero-Fernández B, Rius, C, Sanchez-Martinez H, Gonzalez-Granado JM. Int J Mol Sci. 2023 Jan 31;24(3):2696. doi: 10.3390/ijms24032696. PMID: 36769019

• ​

• Pathophysiology of Inflammatory Bowel Disease: Innate Immune System.  Saez A, Herrero-Fernández B, Gomez-Bris R, Sanchez-Martinez H, Gonzalez-Granado JM. Int J Mol Sci . 2023 Jan 12;24(2):1526. doi: 10.3390/ijms24021526. PMID: 36675038

• ​

• Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease. Saez A, Gomez-Bris R, Herrero-Fernandez B, Mingorance C, Rius C, Gonzalez-Granado JM.Int J Mol Sci . 2021 Jul 16;22(14):7618. doi: 10.3390/ijms22147618.PMID: 34299236

​

• Lamin A/C deficiency in CD4+ T-cells enhances regulatory T-cells and prevents inflammatory bowel disease. Toribio-Fernández R, Herrero-Fernandez B, Zorita V, López JA, Vázquez J, Criado G, Pablos JL, Collas P, Sánchez-Madrid F, Andrés V, Gonzalez-Granado JM. J Pathol. 2019 Dec;249(4):509-522. doi: 10.1002/path.5332. PMID: 31372995

• ​

• Immunobiology of Atherosclerosis: A Complex Net of Interactions. Herrero-Fernandez B, Gomez-Bris R, Somovilla-Crespo B, Gonzalez-Granado JM. Int J Mol Sci. 2019 Oct 24;20(21):5293. doi: 10.3390/ijms20215293. PMID: 31653058

• ​

• CD4 T-cells and Lamin A/C:

• ​

• Lamin A/C and the Immune System: One Intermediate Filament, Many Faces. Saez A, Herrero-Fernandez B, Gomez-Bris R, Somovilla-Crespo B, Rius C, Gonzalez-Granado JM. Int J Mol Sci (020 Aug 25;21(17):6109. doi: 10.3390/ijms21176109. PMID: 32854281

• ​

• ​

• Proliferation and Th1 Differentiation Induced by Bone Marrow-derived Dendritic Cells. Toribio-Fernandez, R, Zorita, V, Herrero-Fernandez, B, Gonzalez-Granado, JM. An In Vivo Mouse Model to Measure Naïve CD4 T Cell Activation,  J. Vis. Exp. 2018 (138), e58118, doi:10.3791/58118.

​

​

​

​

​

​

• ​

​

​

​

​

​

​

​

​

• ​

• Lamin A/C augments Th1 differentiation and response against vaccinia virus and Leishmania major. Toribio-Fernández R, Zorita V, Rocha-Perugini V, Iborra S, Martínez Del Hoyo G, Chevre R, Dorado B, Sancho D, Sanchez-Madrid F, Andrés V, Gonzalez-Granado JM. Cell Death Dis. 2018 Jan 8;9(1):9. doi: 10.1038/s41419-017-0007-6. PMID: 29311549.

• ​

• Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation. González-Granado JM, Silvestre-Roig C, Rocha-Perugini V, Trigueros-Motos L, Cibrián D, Morlino G, Blanco-Berrocal M, Osorio FG, Freije JMP, López-Otín C, Sánchez-Madrid F, Andrés V. Sci Signal. 2014 Apr 22;7(322):ra37. doi: 10.1126/scisignal.2004872. PMID: 24757177.

• ​

• Nuclear envelope lamin-A as a coordinator of T cell activation. Rocha-Perugini V, González-Granado JM. Nucleus. 2014 Sep-Oct;5(5):396-401. doi: 10.4161/nucl.36361. PMID: 25482193

• In Vitro Differentiation of Naïve CD4⁺ T Cells: A Tool for Understanding the Development of Atherosclerosis. Iborra S, González-Granado JM. Methods Mol Biol. 2015;1339:177-89. doi: 10.1007/978-1-4939-2929-0_12. PMID: 26445789

• ​

• Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses. Cruz-Adalia A, Ramirez-Santiago G, Osuna-Pérez J, Torres-Torresano M, Zorita V, Martínez-Riaño A, Boccasavia V, Borroto A, Martínez Del Hoyo G, González-Granado JM, Alarcón B, Sánchez-Madrid F, Veiga E. Nat Commun. 2017 Nov 17;8(1):1591. doi: 10.1038/s41467-017-01661-7. PMID: 29147022.

• ​

• Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity. Morlino G, Barreiro O, Baixauli F, Robles-Valero J, González-Granado JM, Villa-Bellosta R, Cuenca J, Sánchez-Sorzano CO, Veiga E, Martín-Cófreces NB, Sánchez-Madrid F. Mol Cell Biol. 2014 Apr;34(8):1412-26. doi: 10.1128/MCB.01177-13. Epub 2014 Feb 3. PMID: 24492963.

•  

• Tetraspanins 

• ​

• CD9 Regulates Major Histocompatibility Complex Class II Trafficking in Monocyte-Derived Dendritic Cells. Rocha-Perugini V, Martínez Del Hoyo G, González-Granado JM, Ramírez-Huesca M, Zorita V, Rubinstein E, Boucheix C, Sánchez-Madrid F. Mol Cell Biol. 2017 Jul 14;37(15). pii: e00202-17. doi: 10.1128/MCB.00202-17. Print 2017 Aug 1. PMID: 28533221

• ​

• Tetraspanins CD9 and CD151 at the immune synapse support T-cell integrin signaling. Rocha-Perugini V, González-Granado JM, Tejera E, López-Martín S, Yañez-Mó M, Sánchez-Madrid F. Eur J Immunol. 2014 Jul;44(7):1967-75. doi: 10.1002/eji.201344235. Epub 2014 Apr 29. PMID: 24723389 

• ​

• CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses. Rocha-Perugini V, Zamai M, González-Granado JM, Barreiro O, Tejera E, Yañez-Mó M, Caiolfa VR, Sanchez-Madrid F. Mol Cell Biol. 2013 Sep;33(18):3644-58. doi: 10.1128/MCB.00302-13. Epub 2013 Jul 15. PMID: 23858057

• ​

• Cellularity of inflammation:

• Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic Mice. Pan C, Herrero-Fernandez B, et al Circulation. 2023 Feb 28;147(9):774-777

• . 

• High-resolution imaging of intravascular atherogenic inflammation in live mice. Chèvre R, González-Granado JM, Megens RT, Sreeramkumar V, Silvestre-Roig C, Molina-Sánchez P, Weber C, Soehnlein O, Hidalgo A, Andrés V. Circ Res. 2014 Feb 28;114(5):770-9. doi: 10.1161/CIRCRESAHA.114.302590. Epub 2013 Dec 23. PMID: 24366169

• ​

• β2-Adrenoceptor signaling in airway epithelial cells promotes eosinophilic inflammation, mucous metaplasia, and airway contractility. Nguyen LP, Al-Sawalha NA, Parra S, Pokkunuri I, Omoluabi O, Okulate AA, Windham Li E, Hazen M, Gonzalez-Granado JM, Daly CJ, McGrath JC, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9163-E9171. doi: 10.1073/pnas.1710196114. Epub 2017 Oct 9. PMID: 29073113

• ​

• Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. Vila-Caballer M, González-Granado JM, Zorita V, Abu Nabah YN, Silvestre-Roig C, Del Monte-Monge A, Molina-Sánchez P, Ait-Oufella H, Andrés-Manzano MJ, Sanz MJ, Weber C, Kremer L, Gutiérrez J, Mallat Z, Andrés V. J Mol Cell Cardiol. 2019 Jul;132:154-163. doi: 10.1016/j.yjmcc.2019.05.009. PMID: 31121182

• ​

• Immunobiology of Atherosclerosis: A Complex Net of Interactions. Herrero-Fernandez B, Gomez-Bris R, Somovilla-Crespo B Gonzalez-Granado JM Int. J. Mol. Sci. 2019, 20(21), 5293; doi: 10.3390/ijms20215293

•  

• Lamin A/C and nucleus physiology:

• ​

• Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope. González-Granado JM, Navarro-Puche A, Molina-Sanchez P, Blanco-Berrocal M, Viana R, Font de Mora J, Andrés V. PLoS One. 2014 Dec 23;9(12):e115571. doi: 10.1371/journal.pone.0115571. eCollection 2014. PMID: 25535984

• ​

• The nucleus acts as a ruler tailoring cell responses to spatial constraints. Lomakin AJ, Cattin CJ, Cuvelier D, Alraies Z, Molina M, Nader GPF, Srivastava N, Sáez PJ, Garcia-Arcos JM, Zhitnyak IY, Bhargava A, Driscoll MK, Welf ES, Fiolka R, Petrie RJ, De Silva NS, González-Granado JM, Manel N, Lennon-Duménil AM, Müller DJ, Piel M.Science. 2020 Oct 16;370(6514):eaba2894. doi: 10.1126/science.aba2894. PMID: 33060332

​

​

​

​

​

​

​

​

​

​

​

​

​